UltraCol 100 & 200: Effects (Under-Eye, Nasolabial), Price, Swelling, Nodules, and How It Differs From Juvelook
Hello,
This is Dr. Kim Dohoon from ODE Clinic.
At ODE Clinic, we rank among the top nationwide in UltraCol usage and have been selected as a KOL (Key Opinion Leader) clinic for UltraCol 100 and 200.
Based on extensive clinical experience, I’ll walk you through how UltraCol works, its effects, recommended areas, pricing, potential side effects, and how it differs from Juvelook.
How UltraCol Works & Its Effects
UltraCol is a collagen stimulator developed by UltraV, made by processing PDO into fine spherical particles.
1) What is PDO?
PDO (Poly-p-dioxanone):
· Widely used as a material for dissolvable surgical sutures
· Most thread-lifting threads are also PDO-based
Once injected, PDO gradually breaks down over about six months, and during this process, it triggers active collagen production around the particles.
2) Expected Effects of UltraCol
As collagen forms around the PDO particles, you can see:
· Improvement in wrinkles and skin elasticity
· Restoration of volume in hollow areas
Differences Between UltraCol 100 and 200
UltraCol comes in two types—100 and 200.
The biggest distinction is particle size.
1) Particle Size
UltraCol 100: 20–50 μm
UltraCol 200: 50–110 μm
Larger particles induce stronger collagen synthesis, so the choice depends on the treatment goal.
2) Injection Depth & Indications
UltraCol 100
Injection depth: Dermis
Purpose: Texture refinement, fine wrinkles, elasticity improvement
UltraCol 200
Injection depth: Superficial subcutaneous layer
Purpose: Volume enhancement for hollow areas
Because of these differences, the selection depends on the intended improvement.
Recommended Areas for UltraCol 200 – Under-Eye, Nasolabial, Cheeks
1) Under-Eye Hollowness
UltraCol 200 is used for deepening tear troughs caused by aging.
It is especially useful for patients hesitant about fillers or those unsuitable for PLLA-based boosters (like Juvelook) due to nodule risks.
2) Nasolabial Area
It can fill deeper indentations—such as pronounced nasolabial folds and alar recesses—when injected at an appropriate depth, and can also soften more superficial crease lines.
3) Cheek Hollowness
When the mid-cheek looks sunken due to sagging, UltraCol 200 helps restore overall volume.
UltraCol vs. Juvelook
Juvelook is another highly popular collagen booster in Korea.
Here’s how the two compare:
1) Ingredient Difference (PDO vs PLLA)
PDO (UltraCol): Breaks down relatively quickly
PLLA (Juvelook): Breaks down much more slowly
A longer-lasting ingredient is not necessarily safer—
the longer it stays, the higher the nodule risk.
2) Practical Clinical Use
Category | UltraCol | Juvelook |
|---|---|---|
Ingredient | PDO | PLLA |
Breakdown | Fast | Slow |
Best for | Mild hollowness, prioritizing safety, 20s–30s | More pronounced hollowness, stronger effect desired, 40s+ |
The choice varies depending on the degree of volume loss and desired outcome.
UltraCol Pricing (ODE Clinic)
UltraCol 100
3cc (half vial): 300,000 KRW
3cc + Rejuran 2cc: 500,000 KRW
3cc × 3 sessions: 800,000 KRW
UltraCol 200
Under-eye half vial: 350,000 KRW
Under-eye half vial × 3 sessions: 1,000,000 KRW
1 vial × 1 session: 490,000 KRW
1 vial × 3 sessions: 1,350,000 KRW
2 vials × 1 session: 790,000 KRW
2 vials × 3 sessions: 2,150,000 KRW
※ Depending on the area and level of hollowness, the physician will recommend the appropriate amount (half to two vials).
When UltraCol Starts Working · Duration · Treatment Interval
1) Onset of Effects
· Noticeable changes begin around 1 month after treatment
· Collagen synthesis continues up to 6 months, reaching peak results
2) Duration
Varies by individual collagen metabolism, but typically lasts around 1 year.
3) Recommended Treatment Interval
Basic protocol: 3 sessions, 1 month apart
After that: Yearly touch-up
UltraCol Side Effects – Possibility of Nodules
Like other collagen stimulators, UltraCol may cause nodules.
PDO particles can form firm lumps when they:
· Get trapped between muscles, or
· Accumulate in one spot and trigger excessive collagen production
However, compared to PLLA-based products like Juvelook or Sculptra, UltraCol generally has a lower risk of nodules, and many cases naturally resolve over time as the PDO breaks down.
UltraCol Swelling Characteristics
One downside of UltraCol is the swelling immediately after treatment.
· Major swelling: Around 1 week
· Mild residual swelling: Up to 2 weeks in some cases
Patients should be informed beforehand.
How to Choose the Right Clinic for UltraCol
1) A clinic with extensive experience
Collagen stimulators can be unpredictable, so it’s safest to be treated by experienced practitioners.
(ODE Clinic is a high-volume KOL clinic with extensive UltraCol experience. 😊)
2) A clinic with a wide range of treatment options
In addition to UltraCol, it’s best if the clinic also offers:
· Fillers
· Juvelook
· Sculptra
· Radiesse
· Hyalowave, etc.
Because depending on the patient, a different treatment may be more suitable.
3) Consultation directly with the performing physician
It’s important that the physician who performs the procedure is the one who consults and creates the treatment plan.
UltraCol FAQ
Q. Do I need exactly 3 sessions of UltraCol?
A. Not necessarily. While 3 sessions are generally recommended, the number can vary depending on your desired level of improvement.
Q. Does UltraCol have a lifting effect?
A. Not a direct lifting effect, but increased collagen improves elasticity, which can help prevent sagging over time.
Q. Can I receive UltraCol 100 and 200 together?
A. Yes.
Using both together can provide a more balanced result when targeting elasticity, volume, and fine wrinkles at the same time.
Author: Dr. Dohoon Kim, Chief Director of ODE Clinic
Specialty: Anti-aging (Lifting, Volumizing, etc.)