JuveLook Volume Side Effects Complete Guide: Causes, Prevention, and Management

After JuveLook Volume treatment, nodules may occur due to excessive collagen synthesis.

Preventive measures include proper hydration, correct injection techniques, patient screening (including history of autoimmune diseases), and following the one-vial-per-patient rule.

Even if nodules develop, appropriate interventions can help reduce them.

Hello, I am Dr. Dohoon Kim, Chief Physician at ODE Clinic.

In recent years, collagen boosters, particularly JuveLook Volume, have been a major focus in aesthetic treatments. As many of you know, ODE Clinic proudly has experience using over 5,000 vials of JuveLook Volume.

Collagen-stimulating agents can improve various concerns such as wrinkles, pores, skin texture, elasticity, and volume enhancement, even with relatively simple procedures.

However, a major limitation is unpredictability.

• Sometimes the effects may be minimal.

• Excessive collagen synthesis can cause firm nodules.

Today, we will focus on JuveLook Volume nodules, a side effect that concerns many patients.

What Are JuveLook Volume Nodules?

A nodule refers to any abnormal tissue formation under or within the skin that becomes firm to the touch or visible on the surface.

Nodules can occur in various conditions like acne, sebaceous cysts, or skin tuberculosis.

After JuveLook Volume, nodules may appear due to excessive collagen synthesis, which forms firm lumps.

It is important to differentiate simple clumps from true nodules:

1. Simple Clumps

• Appear immediately after treatment.

• JuveLook Volume (PDLLA) particles fail to disperse evenly.

• Often disappear naturally.

• Can be physically dispersed using a cannula and saline.

• May progress to nodules if untreated.

2. Nodules

• Appear 2–3 months after treatment.

• Consist of collagen and immune cells.

• Managed with heat therapy, steroid injections, or oral medications.

• Multiple nodules can occur simultaneously.

If unsure, always consult the treating physician.

Most palpable lumps are actually normal tissue.

Causes and Prevention of JuveLook Volume Nodules

The main cause is insufficient dispersion of the PDLLA particles. To prevent nodules, follow these principles:

1. Adequate Hydration

JuveLook Volume is freeze-dried powder that must be mixed with saline before injection.

Proper hydration allows particles to disperse.

Some clinics hydrate immediately before injection, which risks incomplete dispersion and clumping.

At ODE Clinic, we hydrate each vial for at least 48 hours before use due to the high treatment volume.

2. Skilled Injection Technique

JuveLook Volume should not be injected like a filler.

Unlike fillers, which require concentrated injections to shape an area, JuveLook Volume must be spread evenly across a broader area using a cannula.

This technique reduces nodule risk and requires experience.

The medical staff at ODE Clinic regularly share know-how and knowledge among themselves through private in-house seminars.

3. One Vial per Patient

Dividing a single vial among multiple patients increases infection risk, which can lead to nodules.

We strictly follow the one-vial-per-patient rule, which also ensures sufficient material for precise design.

4. Patient Screening

Patients with a history of autoimmune diseases are at higher risk due to abnormal immune responses.

High-risk areas include the forehead and under-eye regions due to muscle movement and thin skin.

Management of JuveLook Volume Nodules

If nodules occur, visit the clinic for assessment.

1. Spontaneous Resolution
Many nodules shrink and resolve naturally within 1–2 years. No intervention is needed if they are not visible.

2. Visible Nodules

• Oral or injected steroids to control inflammation.

• Heat therapy to soften nodules.

• Physical manipulation to disperse lumps.

A combination of these methods usually reduces or resolves nodules.

While complete prevention is impossible, seeking experienced clinics with a history of nodule management is crucial.

Many patients seeking JuveLook Volume are hesitant about fillers.

Pre-treatment, some are overly sensitive about nodules, and most post-treatment concerns are normal collagen formations.

If very cautious, it is worth considering collagen stimulators with proper guidance.

For further questions, please contact our clinic.

Dr. Dohoon Kim, ODE Clinic

Author: Dr. Dohoon Kim, Chief Director of ODE Clinic
Specialty: Anti-aging (Lifting, Volumizing, etc.)