Re2O Skin Booster Complete Guide | Effects, Duration, Price, Side Effects, Pain Level, and Comparison with Rejuran & Juvelook

Re2O Skin Booster is a treatment that uses hADM (human Acellular Dermal Matrix), which involves transplanting human-derived dermal tissue as it is. By increasing collagen and elastin, it helps improve skin elasticity, pores, wrinkles, and texture. The effects last for about one year after a single treatment, and it is known for being minimally painful yet highly effective.

What is Re2O Skin Booster?

Unlike past skin boosters that indirectly stimulated collagen production, Re2O directly implants human Acellular Dermal Matrix (hADM) — actual dermal tissue derived from the human body.
Because it uses human-derived tissue, it has excellent biocompatibility, causing fewer allergic or nodule-related side effects while delivering superior collagen regeneration effects.

‘hADM’ literally means human skin tissue that has been completely decellularized.
By eliminating immune cells and potential allergens, it minimizes the risk of allergic reactions.

It contains collagen, elastin, hyaluronic acid, and other essential components that naturally make up the skin’s structure.

Main Benefits of Re2O Skin Booster

After the Re2O treatment, patients can expect the following results:

1. Improved Skin Elasticity

Collagen regeneration occurs throughout the dermal layer, restoring elasticity.
As the skin becomes firmer, sagging improves and can even be prevented, similar to the effect of Thermage tightening.

2. Reduction of Wrinkles, Pores, and Uneven Texture

As the skin becomes plumper, surface irregularities are smoothed out.
Fine lines, enlarged pores, and rough texture improve, and light reflects more evenly, giving the skin a healthy glow.

Re2O Treatment Methods and Pain Level

There are several methods for performing the Re2O Skin Booster procedure — manual injection, injector device, and cannula technique.

1. Manual and Injector Method

This approach involves direct needle injections into the desired areas.
It allows precise placement of the material with minimal loss, but tends to cause more pain and bruising.

2. Cannula Technique

This method uses a blunt-tipped flexible tube inserted under the skin — similar to a filler procedure.
Although some patients may feel uncomfortable with the cannula moving beneath the skin, it generally causes less pain and bruising, and delivers more even, natural results.

At ODE Clinic, we tailor the treatment to each patient’s preference, though we generally recommend the cannula method for optimal comfort and results.

When Do You See Results? How Long Do They Last?

You can begin to see the effects of Re2O about two weeks after the procedure.

Once new collagen and elastin are formed, the results typically last around one year.
However, since collagen naturally breaks down with age, results may vary from person to person.

If you wish to enhance your results before a full year passes, additional sessions can be safely performed at any time.

Re2O Price and Recommended Schedule

The price of Re2O Skin Booster varies by clinic.
At ODE Clinic, the cost is ₩600,000 per syringe (VAT not included).

A full course of three sessions spaced one month apart totals ₩1,800,000.

After completing one cycle, we recommend a maintenance session once a year.
For further improvements, it’s often more effective to combine Re2O with other treatments that use different mechanisms rather than repeating the same procedure.

At ODE Clinic, we use skin diagnostic imaging to compare before-and-after results and create a personalized treatment plan through direct one-on-one consultation with our doctors.

Possible Side Effects and Precautions

Like any procedure, Re2O may have side effects.

1. Allergic Reactions

Some patients may experience redness, itching, or swelling due to immune response.
In such cases, oral medications can be prescribed to control symptoms.
While this reaction is unpredictable, it is quite rare.

2. Nodules

Because Re2O also stimulates collagen synthesis, small nodules may occasionally appear.
However, it’s not designed to trigger continuous inflammation, so the risk is much lower than with Sculptra, Juvelook, or Radiesse.

Still, it’s important to choose an experienced provider for safe and effective results.

Re2O vs Rejuran vs Juvelook

Let’s compare Re2O with the two most well-known skin boosters — Rejuran and Juvelook.

(1) Re2O vs Rejuran

These two treatments work in different ways.
If Re2O provides the “building materials” — like bricks and cement — for creating a strong skin structure made of collagen and elastin,
Rejuran focuses on revitalizing the cells within that structure.

Therefore, Re2O primarily targets elasticity, wrinkles, pores, and texture,

while Rejuran improves overall skin quality, regeneration, hydration, and pigmentation.

• Rejuran: for general skin rejuvenation and radiance

• Re2O: for focused improvement in elasticity, wrinkles, and pores

(2) Re2O vs Juvelook

Juvelook also promotes collagen synthesis, similar to Re2O.
However, Juvelook uses synthetic polymer-based materials, which can cause high variability between individuals.

Some people see minimal results, while others experience excessive collagen formation leading to nodules.

For those seeking a safer and more consistent option, Re2O — derived from human dermal tissue — is the better choice.

Summary

In summary, Re2O Skin Booster is a next-generation treatment ideal for those who want to improve pores, fine lines, texture, and skin elasticity, especially if previous boosters didn’t deliver satisfying results.

If you’d like to know more, feel free to leave a comment anytime —
this has been Dr. Dohoon Kim from ODE Clinic.

Author: Dr. Dohoon Kim, Chief Director of ODE Clinic
Specialty: Anti-aging (Lifting, Volumizing, etc.)