Complete Guide to Juvelook Volume | Effects, Duration, Side Effects, and How to Choose the Right Clinic

We’ll cover everything about Juvelook Volume—the difference from Juvelook Skin, how collagen regeneration works, which areas respond best, how long it lasts, and even how to avoid side effects like nodules.
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Nov 07, 2025
Complete Guide to Juvelook Volume | Effects, Duration, Side Effects, and How to Choose the Right Clinic

Juvelook Volume uses PDLLA particles to stimulate collagen production, improving skin elasticity and volume.
It’s especially effective for nasolabial folds and hollow cheeks, with results lasting over two years, unlike typical fillers.


Hello,
I’m Dr. Dohoon Kim from ODE Clinic.

Our clinic has specialized in collagen boosters and fillers for years, and among them, Juvelook Volume is one of our signature procedures. Today, I’ll explain it clearly and thoroughly.

Gangnam ODE Clinic Achieves 5,000 Vials of Juvelook Volume Treatment
Gangnam ODE Clinic Achieves 5,000 Vials of Juvelook Volume Treatment

Our medical team has performed over 5,000 Juvelook Volume procedures safely and effectively, combining deep anatomical knowledge with precision technique.


How Juvelook Works

Juvelook is made from PLA (Polylactic Acid), a natural material extracted from sugarcane, which is processed into PDLLA, a biocompatible polymer.


Once injected, these particles trigger a mild inflammatory response that activates collagen synthesis, lasting for over a year.

In short, Juvelook is a collagen stimulator.


Juvelook Skin vs Juvelook Volume

The main difference lies in particle size and concentration:

Juvelook Skin Product Photo
Juvelook Skin Product

  • Juvelook Skin: smaller particles injected into the dermis for texture improvement and fine wrinkles.

Juvelook Volume Product Photo
Juvelook Volume Product

  • Juvelook Volume: larger particles injected into the subcutaneous fat layer, restoring volume and firmness.

Recent studies also show that PDLLA promotes adipocyte (fat cell) regeneration, not just collagen synthesis—about 70% elasticity improvement and 30% volume enhancement.

The paper data on changes after PDLLA injection of Juvelook Volume
Source: Poly-D,L-Lactic Acid Fillers Increase Subcutaneous Adipose Tissue Volume by Promoting Adipogenesis in Aged Animal Skin

Product

Particle Size

PDLLA Content

Target Layer

Main Effects

Juvelook Skin

~30μm

50mg

Dermis

Wrinkles, pores

Juvelook Volume

50–80μm

200mg

Subcutaneous fat

Volume, elasticity


Juvelook Volume vs Fillers

Fillers offer immediate results by adding material directly under the skin, while Juvelook Volume gradually fills sunken areas by stimulating collagen growth.

  • For instant volume, choose fillers.

  • For natural firmness and long-term improvement, choose Juvelook Volume.

Category

Juvelook Volume

Filler

Main ingredient

PDLLA

Hyaluronic Acid

Onset

After 6 months

Immediate

Effect ratio

70% elasticity / 30% volume

100% volume

Target areas

Nasolabial folds, cheeks

Most facial areas

Duration

2+ years

About 1 year

Dissolvable

No

Yes

Main side effect

Nodules

Vascular occlusion, migration


Best Treatment Areas

Juvelook Volume works best for nasolabial folds and hollow cheeks.

Actual Juvelook Volume Effect on Nasolabial Folds
Before and After Juvelook Volume Nasolabial Fold Treatment

For those with broad cheek depressions, Juvelook Volume not only restores fullness but also improves skin elasticity.

Actual Juvelook Volume Effect on Cheek Hollows
Before and After Juvelook Volume Hollow Cheeks Treatment


In contrast, the forehead and under-eye areas are not recommended for this treatment, for the following reasons:

  • Forehead: Since shape contouring is important, fillers are more suitable, as they allow the doctor to sculpt the desired shape precisely.

    Forehead hollows are more suitable for filler treatment
    Before and After Filler Forehead Treatment

  • Under the eyes: This area has many muscles and blood vessels, and the skin is thin, making nodules more noticeable if they occur.
    Therefore, fillers are preferable, and for collagen-stimulating options, UltraCol is recommended.

    Areas under the eyes are prone to side effects during Juvelook Volume treatment
    Before and After Eyefiller Treatment


Longevity and Treatment Interval

Results begin to appear about 3 months after injection, and collagen synthesis continues for up to 2 years.


The visible effects typically last 2–3 years.

At ODE Clinic, our patients usually return for a follow-up about a year and a half after completing three treatment sessions spaced one month apart.

During this visit, we compare skin analysis photos to assess the progress and discuss together whether additional treatments or adjustments are needed.

This is why a one-on-one consultation with your doctor is absolutely essential.


Possible Side Effect: Nodules

  1. What are nodules?
    Occasionally, particles may clump together or trigger excessive collagen formation, leading to firm, visible bumps.

  2. How are they treated?

  • Single nodule: thermal energy or steroid injections

  • Multiple nodules: oral steroids and immune modulation

  1. How to prevent nodules:

  • Proper hydration for 24+ hours before injection

  • Skilled cannula technique

  • Avoiding injection in high-risk or autoimmune-prone patients

  • Using one vial per patient only


Choosing the Right Clinic

  1. Experience matters. Choose a clinic with extensive track records.

  2. Doctor consultation. You should meet the operating doctor directly, not just a consultant.

  3. Avoid “factory-style” clinics. If different doctors perform each session, consistent results and follow-ups become impossible—especially in case of complications.


Frequently Asked Questions

Q. How often do nodules occur?
A. Less than 1 in 1,000 patients.

Q. Can I get fillers after Juvelook Volume?
A. Yes. You can first enhance your base volume with Juvelook, then refine shape later with a small amount of filler.

Q. How does Juvelook Volume differ from Sculptra?
A. Sculptra tends to have stronger collagen-stimulating power and longer clinical history, though Juvelook is known for lower nodule risk due to its porous microstructure.


For more details, feel free to visit ODE Clinic anytime.
— Dr. Dohoon Kim, ODE Clinic


Author: Dr. Dohoon Kim, Chief Director of ODE Clinic
Specialty: Anti-aging (Lifting, Volumizing, etc.)

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