Complete Guide to Juvelook Volume | Effects, Duration, Side Effects, and How to Choose the Right Clinic
Juvelook Volume uses PDLLA particles to stimulate collagen production, improving skin elasticity and volume.
It’s especially effective for nasolabial folds and hollow cheeks, with results lasting over two years, unlike typical fillers.
Hello,
I’m Dr. Dohoon Kim from ODE Clinic.
Our clinic has specialized in collagen boosters and fillers for years, and among them, Juvelook Volume is one of our signature procedures. Today, I’ll explain it clearly and thoroughly.

Our medical team has performed over 5,000 Juvelook Volume procedures safely and effectively, combining deep anatomical knowledge with precision technique.
How Juvelook Works
Juvelook is made from PLA (Polylactic Acid), a natural material extracted from sugarcane, which is processed into PDLLA, a biocompatible polymer.
Once injected, these particles trigger a mild inflammatory response that activates collagen synthesis, lasting for over a year.
In short, Juvelook is a collagen stimulator.
Juvelook Skin vs Juvelook Volume
The main difference lies in particle size and concentration:

Juvelook Skin: smaller particles injected into the dermis for texture improvement and fine wrinkles.

Juvelook Volume: larger particles injected into the subcutaneous fat layer, restoring volume and firmness.
Recent studies also show that PDLLA promotes adipocyte (fat cell) regeneration, not just collagen synthesis—about 70% elasticity improvement and 30% volume enhancement.

Product | Particle Size | PDLLA Content | Target Layer | Main Effects |
|---|---|---|---|---|
Juvelook Skin | ~30μm | 50mg | Dermis | Wrinkles, pores |
Juvelook Volume | 50–80μm | 200mg | Subcutaneous fat | Volume, elasticity |
Juvelook Volume vs Fillers
Fillers offer immediate results by adding material directly under the skin, while Juvelook Volume gradually fills sunken areas by stimulating collagen growth.
For instant volume, choose fillers.
For natural firmness and long-term improvement, choose Juvelook Volume.
Category | Juvelook Volume | Filler |
|---|---|---|
Main ingredient | PDLLA | Hyaluronic Acid |
Onset | After 6 months | Immediate |
Effect ratio | 70% elasticity / 30% volume | 100% volume |
Target areas | Nasolabial folds, cheeks | Most facial areas |
Duration | 2+ years | About 1 year |
Dissolvable | No | Yes |
Main side effect | Nodules | Vascular occlusion, migration |
Best Treatment Areas
Juvelook Volume works best for nasolabial folds and hollow cheeks.

For those with broad cheek depressions, Juvelook Volume not only restores fullness but also improves skin elasticity.

In contrast, the forehead and under-eye areas are not recommended for this treatment, for the following reasons:
Forehead: Since shape contouring is important, fillers are more suitable, as they allow the doctor to sculpt the desired shape precisely.

Before and After Filler Forehead Treatment Under the eyes: This area has many muscles and blood vessels, and the skin is thin, making nodules more noticeable if they occur.
Therefore, fillers are preferable, and for collagen-stimulating options, UltraCol is recommended.
Before and After Eyefiller Treatment
Longevity and Treatment Interval
Results begin to appear about 3 months after injection, and collagen synthesis continues for up to 2 years.
The visible effects typically last 2–3 years.
At ODE Clinic, our patients usually return for a follow-up about a year and a half after completing three treatment sessions spaced one month apart.
During this visit, we compare skin analysis photos to assess the progress and discuss together whether additional treatments or adjustments are needed.
This is why a one-on-one consultation with your doctor is absolutely essential.
Possible Side Effect: Nodules
What are nodules?
Occasionally, particles may clump together or trigger excessive collagen formation, leading to firm, visible bumps.How are they treated?
Single nodule: thermal energy or steroid injections
Multiple nodules: oral steroids and immune modulation
How to prevent nodules:
Proper hydration for 24+ hours before injection
Skilled cannula technique
Avoiding injection in high-risk or autoimmune-prone patients
Using one vial per patient only
Choosing the Right Clinic
Experience matters. Choose a clinic with extensive track records.
Doctor consultation. You should meet the operating doctor directly, not just a consultant.
Avoid “factory-style” clinics. If different doctors perform each session, consistent results and follow-ups become impossible—especially in case of complications.
Frequently Asked Questions
Q. How often do nodules occur?
A. Less than 1 in 1,000 patients.
Q. Can I get fillers after Juvelook Volume?
A. Yes. You can first enhance your base volume with Juvelook, then refine shape later with a small amount of filler.
Q. How does Juvelook Volume differ from Sculptra?
A. Sculptra tends to have stronger collagen-stimulating power and longer clinical history, though Juvelook is known for lower nodule risk due to its porous microstructure.
For more details, feel free to visit ODE Clinic anytime.
— Dr. Dohoon Kim, ODE Clinic
Author: Dr. Dohoon Kim, Chief Director of ODE Clinic
Specialty: Anti-aging (Lifting, Volumizing, etc.)